See the bottom of this page for a description of the icons on the page.

• Microarray Gene Expression Patterns - a gene expression analysis
• Patient Quality of Life - an exhaustive regression analysis to identify the specific factors that ease the suffering of chemotherapy recipients
• Protein Folding - a study of the molecular dynamics of protein folding to create greater understanding of the behavior of cancer cells and how they interact with potential new treatments

Note: the project may have ended in 2010. The project website has been unreachable since May, 2010, but the project is still listed as active here.

The project runs on the Parabon Computation Frontier Compute Engine platform. To participate in the project, download and run the project's secure Java client. As of January 15, 2007, the client is available for Windows (XP/Vista/2000), Linux (2.4 kernel or higher), and Mac OSX (version 10.2 or later).

On October 21, 2002, the project announced that it achieved its initial goal: to "simulate the folding dynamics of proteins and make quantitative predictions for how [protein folding] works. This has been a 'holy grail' of computational biology." Specifically, the project simulated the folding of a man-made chain of 23 amino acids called BBA5. The simulation's measurements and folding-time matched physical measurements and folding-time of the protein observed in a lab. The achievement was published in the November, 2002, edition of Nature, in an article titled "Absolute comparison of simulated and experimental protein-folding dynamics." In October and November, 2004, the project's lead developer and research scientist, Guha Jayachandran, won the top award at the 2004 Biomedical Computation at Stanford (bcats) conference, and Vijay Pande has been named a 2004 Technovator.

On January 10, 2003, the project broke the 90,000 active CPU mark. On October 10, 2003, it broke the 120,000 active CPU mark. On April 24, 2004, it broke the 150,000 active CPU mark. On September 9, 2004, it broke the 1,000,000 total CPUs and 100 TFLOPs marks. On January 14, 2005, it broke the 170,000 actuve CPU mark. On September 20, 2005, it broke the 200,000 active CPU mark.

On November 28, 2001, the project began studies (110 and 5100) on Alzheimer's Disease. On May 8, 2002, the project began studies (503 and 504) on Huntington's Disease, a disease similar to Alzheimer's Disease in that it is caused by protein misfolding. See a list of all of the project's current studies. In June, 2002, the project started using the Gromacs molecular dynamics modeling software. This software allows the project to simulate larger proteins more accurately and much more quickly than the previous software. As of August 12, 2002, the Gromacs software has successfully modeled one of the simpler molecules, project 902, and shows a lot of promise for success with larger molecules. On March 27, 2003, the project began studying several new types or work units, including NTL9 (a protein with both beta and alpha structure) and 1PRB (a three-helix bundle). The project also increased the scope of its trpzip investigation to include a fourth variant trpzip4. On April 23, 2004, it published the first results from its Gromacs core. On August 20, 2004, the project began its P130x projects: these projects have work units much larger than normal, and require users to have hundreds of MB of RAM and be able to transfer 5 MB of data for each result, but the work units have 50% more value in stats. On October 12, 2004, the project released a new AMBER (Assisted Model Building with Energy Refinement) core which will allow it to do things that it can't with its existing Tinker and Gromacs cores. See the AMBER core FAQ. On January 15, 2005, the project published the results of its p53 tumor suppressor study, part of its cancer research project. These results are "the first peer-reviewed results from a distributed computing project related to cancer." On December 22, 2009, the project released a new core (Protomol core B4), which implements "the NML (Normal Mode Langevin) method" of protein folding simulation. If it is successful, this method could be up to one hundred times faster than previous cores.

On September 18, 2008, the project released an updated version of its PlayStation 3 client, now included in a Life With PlayStation feature on the PlayStation 3 console, which does more complex scientific calculations and which displays a more detailed globe, with weather and news reports for major cities plus a real-time map of cloud cover over the globe.

On February 18, 2009, the project passed the 5 PetaFLOPs mark. At that time traditional supercomputers were just passing the 1 PetaFLOPs mark. "The use of GPU's and Cell processors is has been key to this, and in fact the NVIDIA numbers alone have just passed 2 petaflops."

On January 17, 2010, the project announced it successfully achieved the first protein folding simulation on a millisecond timescale. This achievement is 1,000 times more difficult than the project's initial goal of simulation millisecond timescale simulation. The project published its 72d paper, Molecular Simulation of ab Initio Protein Folding for a Millisecond Folder NTL9(1-39), about the achievement.

On June 27, 2010, the project published a paper, "Atomic-Resolution Simulations Predict a Transition State for Vesicle Fusion Defined by Contact of a Few Lipid Tails," describing the project's "work on the mechanism for vesicle fusion," an important part of the process in which a virus infects a cell. Learning about this mechanism will help scientists better understand how the influenza virus enters cells.

Version 5.02 of some of the Windows, Linux and Mac OS X clients is available as of August 20, 2004. Version 4.00 of the other clients is available as of December 19, 2003. Note the 2.x clients have a compatibility problem, and you should upgrade to the latest client if you are using an old version. Beta version 5.04 of the client is available for Windows and Linux for testing as of July 25, 2005.

Students and teachers should see the Education@Home section of the site.

See the research papers and articles published from the results of this project.

See Professor Pande's February 19, 2004, talk at Xerox PARC: Folding@Home: Can a grid of 100,000 CPUs tackle fundamental barriers in molecular simulation? Windows Media Player is required to view the video.

See independently-maintained hourly team and user stats for this project at statsman.org.

See an independent support site for helpful hints about participating in this project.

See the original Folding@Home project.

Join a discussion forum about this project.

Join a discussion forum about the original project.

Join an independent discussion forum about ab-initio protein folding (where the folding is simulated completely in software)

The project completed Phase I on May 21, 2003 (in this phase, almost 60,000 computers completed 1,400 years of computing to process over 9 million tasks).

"[Phase I] has ably demonstrated that with such massive computational abilities, researchers can utilize intensive approaches to identify drug candidates that succumb to resistance mutations and those that are more resilient to such mutations. An early lead developed during Phase I, TL-3, has been shown to be promising against the drug resistant strains that have arisen from the currently approved HIV Protease inhibitors. The characteristics of TL-3 have been born out by the FAAH computational work."

The project began Phase II on May 21, 2003. Note that for Phase II, the project transfered completely to The Scripps Research Institute (and became a completely non-profit project) and Entropia is no longer involved. You will need to reregister and download a new client to participate in Phase II. You can learn more about the project through articles it published on January 19 and January 26, 2004:
The Resistance Part I: From Petri Dishes to Population Dynamics
The Resistance Part II: Fighting HIV Resistance At Home and in the Laboratory.
For Phase II, the project has completed 4 experiments so far. Experiment 1a tested almost 1,900 compounds (of a possible 200,000) available from the National Institutes of Health against "a panel of 270 variations of the HIV protease structure" for a total of 513,000 experiments. Experiment 1a ended in April, 2006. Experiment 1b docked "all 200,000 compounds in the NIH library against the ‘wild-type’ HIV protease." That experiment ended in June, 2006. Experiment 2 completed the following tests: ChemBridge (500,000) vs. Wild Type HIV Protease (1); Top Hits from Experiment 1 vs. Mutant HIV Protease Panel (270); NCI Diversity Set (1,900) vs. Monomeric HIV Protease (20). It began in June, 2006, and end later in 2006. Experiment 3 tested Sidechain Motion in HIV Protease Cross Dockings. It ended in late 2006. Experiment 4 tested NCI Diversity Set vs. HIV PR Monomer. It ended in late 2006. Experiment 5 is testing BindingDB vs. HIV Protease, with and without Active Site Water Molecule.

On February 3, 2010, the project announced it found two compounds that make a completely new class of AIDS-fighting drugs possible: "two compounds that act on novel binding sites for an enzyme used by the human immunodeficiency virus (HIV), the virus that causes AIDS. The discovery lays the foundation for the development of a new class of anti-HIV drugs to enhance existing therapies, treat drug-resistant strains of the disease, and slow the evolution of drug resistance in the virus."

The project began Experiment 33 on June 3, 2010. This is the first experiment which targets the HIV integrase system. The experiment is screening over 360,000 protein fragments and some larger compounds "against our new dynamic models of the E92Q/N155H drug-resistant mutant of HIV-1 integrase," searching for compounds which can attach to brand new binding sites on this mutant.

The project published Volume 8 of its newsletter on November 2, 2009.

On November 19, 2005, the project joined the World Community Grid. The original software client is not supported as of that date. Users of the original client can follow easy migration instructions to move to the World Community Grid client, and World Community Grid participants can follow the directions on the new download page to ensure their client is participating in fightAIDS@home. A BOINC client for Linux should be available soon.

See a white paper about this process: The Virtual Laboratory: Enabling Molecular Modeling, and a PhD thesis. The biology collaborator working on this project has already designed a drug to counteract an ECE enzyme involved in heart stroke, and is currently using the Virtual Laboratory to study liver cancer.

See another white paper by the project coordinators: Grids and Grid Technologies for Wide-Area Distributed Computing.

Note: this project is currently only for Linux/Unix users. Windows is not supported yet.

Note that this project is in its alpha test phase. Credits and results m ay be reset or deleted at any time.

Note: The Brooks Research Group [the group that owns this project] will be relocating to the University of Michigan in December, 2007. The project and website were transferred to Ann Arbor, Michigan in late 2007 and early 2008. The project may not be active again until 2010 or 2011.

The top 5 predictions for targets T0196 and T0197 are available as of July 1, 2004. You can see them in the project's gallery.

The project uses the BOINC computing platform. See the BOINC platform information for the latest version of the BOINC client. The BOINC client is available for Windows, Linux and Mac OSX. Note that the client needs 150 MB of disk space and 50 MB of RAM to run. You may need to adjust your available disk and memory percentages to allow the client to use these amounts. The project server was upgraded to BOINC 4 in November, 2004. The project supports BOINC version 4.2x clients as of March 2, 2005.

Join a discussion forum about the project.

The project's results database was first accessed by researchers on September 26, 2005.

The project uses the BOINC computing platform to run various applications. See the BOINC platform information for the latest version of the BOINC client. If you already have BOINC installed, you can join this and other World Community Grid BOINC-based project by attaching to the project URL www.worldcommunitygrid.org. You can select/de-select World Community Grid projects in your World Community Grid member page, under My Grid --> My Projects.

This project is discussed in the World Community Grid forums.

The project uses the BOINC computing platform. See the BOINC platform information for the latest version of the BOINC client. The BOINC client is available for Windows, Linux and Mac OSX. Version 5.25 of the Rosetta application is available for Windows, Linux and Mac OSX as of June 20, 2006.

See a 7 minute YouTube video about the project. The video was created on January 7, 2007.

Join a discussion forum about the project.

The project uses the BOINC computing platform. See the BOINC platform information for the latest version of the BOINC client. The BOINC client is available for Windows, Linux and Mac OSX.

Join a discussion forum about the project.

The project had over 10,000 hosts and 5,000 users with credits, and has calculated the similarities for more than 1 million protein sequences, as of March 22, 2006.

The project uses the BOINC computing platform. See the BOINC platform information for the latest version of the BOINC client. Version 5.11 of the SIMAP application is available for Linux as of July 17, 2006. Version 5.10 is available for Windows and Mac OSX as of July 12, 2006. Versions 5.6 and later reduce the calculation time per work unit to 1/10th that of previous versions. Dialup users should be aware that work units are about 1.5 MB and results are about 1.3 MB.

Join a discussion forum about this project.

On September 17, 2007, the project began testing a third science application called optimizer. This application is run as a test application, "meaning that only users who have 'run test applications' and 'run optimizer application' checked in their account settings (under malariacontrol.net preferences) will get work, and only Windows users will get work. Results from the optimizer application are helping the project team "to improve the main malariacontrol application in the future."

As of March 1, 2010, the project is preparing new work units for its next phase of research.

In October, 2008, the project published its first results, a paper titled What Should Vaccine Developers Ask? Simulation of the Effectiveness of Malaria Vaccines.

The project uses the BOINC computing platform to run various applications. See the BOINC platform information for the latest version of the BOINC client. See the project's Applications page for a list of the project's current applications and versions.

Join a discussion forum about this project.

Note: The project's server accidentally went down on August 18, 2008. The project team is repairing the server. The project is on hold in the meantime.

The project uses a BOINC-based client. See the BOINC platform information for the latest version of the BOINC client. Version 5.99 of the BD client is available for Windows, Linux and Mac OSX as of October 1, 2007.

The project's first research project was "complex 1HVI: the Hiv-1 protease complexed with the inhibitor A77003." On September 10, 2008, it began researching "model 13sc. This model keeps track of the ligand structure, enabling the study of initial conditions in our simulations."

The project began its public Beta test on September 3, 2008, and opened public account registration on September 8, 2008.

The project uses a BOINC-based client. See the BOINC platform information for the latest version of the BOINC client. The project is currently in Beta testing. See the project's Applications page for a list of the project's current applications and versions.

Join a discussion forum about this project.

The project team published its first paper, "Computational protein design: Software implementation, parameter optimization, and performance of a simple model," on December 10, 2007.

The project uses a BOINC-based client. See the BOINC platform information for the latest version of the BOINC client. The project is currently in Alpha testing. Version 7.41 of the Xplor client is available for Windows as of February 1, 2008.

Join a discussion forum about this project.

Phase 1 of the project performed cross-docking calculations on over 150 proteins, to see how well each protein iteracts with each of the other proteins. See more information about Phase 1. This phase ended on June 11, 2007. In the 7 months that Phase 1 ran, "106,000 members will have donated more than 8,000 years of computer time on 154,000 different computers," and computed 5,416,082 results. Phase 2 should begin in 2008. Phase 2 began in May, 2009. It is "investigating protein-protein interactions for more than 2,200 proteins whose structures are known, with particular focus on those proteins that play a role in neuromuscular diseases." See more information about Phase 2.

See the project's Phase 1 FAQ and Phase 2 FAQ.

The project uses the World Community Grid computing platform. Participants are encouraged to participate through World Community Grid. See World Community Grid platform information for the latest version of these platform clients. The clients are currently available for Windows, Linux and Mac OSX. Please review the clients' system requirements.

Join a discussion forum about World Community Grid's projects.

The project completed Phase 1 (a screening process for over 3 million potential drug molecules) on August 26, 2009. Project participants contributed over 12,000 years of computing time to Phase 1. The results of Phase 1 benefit research not only for Dengue Fever but also for Hepatitis C, West Nile, Yellow Fever and other diseases caused by the Flaviviridea family of viruses. Phase 2 will perform more in-depth analysis on the best candidates found in Phase 1. The best candidates found in Phase 2 will be tested in labs.

The project began Phase 2 on March 23, 2010. This phase is reducing the number of "false positive" (i.e. dead end) results from phase 1.

The project uses the BOINC computing platform to run various applications. See the BOINC platform information for the latest version of the BOINC client. If you already have BOINC installed, you can join this and other World Community Grid BOINC-based project by attaching to the project URL www.worldcommunitygrid.org. You can select/de-select World Community Grid projects in your World Community Grid member page, under My Grid --> My Projects.

This project is discussed in the World Community Grid forums.

The project uses a BOINC-based client. See the BOINC platform information for the latest version of the BOINC client. Versions 5.09, 5.10, 5.11 and 5.12 of the GARLI client are available for Windows, Linux and Mac OSX as of December 18, 2007. Version 5.05, 5.06 and 5.10 of the HMMPfam client are available for Windows, Linux and Mac OSX as of December 18, 2007. Version 5.02 of the MARXAN client is available for Windows as of December 18, 2007.

Join a discussion forum about this project.

• predict the biologically active structure of proteins
• understand the signal-processing mechanisms when the proteins interact with one another
• understand diseases related to protein malfunction or aggregation
• develop new drugs on the basis of the three-dimensions structure of biologically important proteins.

This project participated in the CASP8 protein structure prediction contest, which occured between May 5, 2008 and August 1, 2008. Results from the contest were released at the CASP meeting on December 3-7, 2008, and were published at PlanetBOINC.

The project uses a BOINC-based client. See the BOINC platform information for the latest version of the BOINC client. Versions 0.07 of the POEM Protein Folding application is available for Windows as of November 29, 2007. Version 0.08 is available for Linux and Mac OS X as of January 11, 2008.

Join a discussion forum about this project.

As of June 15, 2010, the project has sifted through more than 100 million images of 12,500 unique proteins which may be linked to cancer. These pictures were taken during 19.2 million experiments. This project allows scientists to get results six times faster than by using traditional methods.

The project uses the BOINC computing platform to run various applications. See the BOINC platform information for the latest version of the BOINC client. If you already have BOINC installed, you can join this and other World Community Grid BOINC-based project by attaching to the project URL www.worldcommunitygrid.org. You can select/de-select World Community Grid projects in your World Community Grid member page, under My Grid --> My Projects.

This project is discussed in the World Community Grid forums.

The project uses a BOINC-based client. See the BOINC platform information for the latest version of the BOINC client. Versions 1.00 of the Cels@Home application is available for Windows as of February 25, 2008.

Join a discussion forum about this project.

The project uses a BOINC-based client. See the BOINC platform information for the latest version of the BOINC client. Versions 3.00 of the project's client application is available for Windows, Linux and Mac OS X as of March 5, 2008.

Join a discussion forum about this project.

Join a discussion forum about the beta test project.

The project uses a BOINC-based client. See the BOINC platform information for the latest version of the BOINC client. Versions 5.57 of the project's malariacontrol client application is available for Windows and Linux as of April 17, 2008.

Join a discussion forum about this project.

The project uses the BOINC computing platform to run various applications. See the BOINC platform information for the latest version of the BOINC client. If you already have BOINC installed, you can join this and other World Community Grid BOINC-based project by attaching to the project URL www.worldcommunitygrid.org. You can select/de-select World Community Grid projects in your World Community Grid member page, under My Grid --> My Projects.

This project is discussed in the World Community Grid forums.

The project uses the BOINC computing platform to run various applications. See the BOINC platform information for the latest version of the BOINC client. If you already have BOINC installed, you can join this and other World Community Grid BOINC-based project by attaching to the project URL www.worldcommunitygrid.org. You can select/de-select World Community Grid projects in your World Community Grid member page, under My Grid --> My Projects.

This project is discussed in the World Community Grid forums.

The project uses a BOINC-based client. See the BOINC platform information for the latest version of the BOINC client. See the project's applications page for a list of its clients, their latest versions, and the platforms they are available for.

Join a discussion forum about this project.